Doctor's Best Vitamin D3 Description. •Science-Based Nutrition™•2000 IU Vitamin D3 per Serving•Supports Healthy Immune System, Heart, & Bone HealthVitamin D3 (cholecalciferol) is a nutrient that is critical to many bodily functions. Vitamin D3 is beneficial for supporting
•Supports Healthy Immune System, Heart, & Bone Health
Vitamin D3 (cholecalciferol) is a nutrient that is critical to many bodily functions. Vitamin D3 is beneficial for supporting bone health, immune wellness, cardio- vascular function, and cellular metabolism, among others. Mounting research is highlighting the ever-increasing benefits of optimal vitamin D3 status. Vitamin D3 is known to interact with over 200 different genes and thus plays a crucial regulatory role as a metabolic activator for a multitude of metabolic processes.
Vitamin D from dietary intake or sun exposure requires two activation steps in the body. The first activation occurs in the liver, while the second activation occurs in the kidneys, allowing for regulation of calcium metabolism. However, vitamin D receptors are present throughout the body, in tissue such as the skin, cartilage, heart, prostate, bones and intestines. Thus, the second activation step also takes place in local tissues. Recent discoveries have highlighted the important modulatory effects of vitamin D on various cells of the immune system.
Vitamin D enhances and regulates immune function
Studies show that vitamin D has important immunomodulatory effects. It is known that various cells of the immune system, such as T lymphocytes and antigen presenting cells, express the vitamin D receptor on their surface when activated. Recently, it has been found that treatment of these immune cells with vitamin D influences their expression of cytokines, which are chemical messengers of the immune system. The immune modulating effects of vitamin D extend to monocytes and dendritic cells of the immune system as well. Dendritic cells are important antigen-processing cells of the immune system that function to initiate the immune response. By altering the cytokine expression of dendritic cells, vitamin D may prevent overactivity of the immune response and keep the immune system in a normal healthy state of vigilance.
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